Stamets Stack

Microdosing activated mushrooms has increased in popularity as of late, thanks to the wide array of possible health benefits. One figure at the center is Paul Stamets, an expert who recommends “stacking” activated mushrooms with other compounds to maximize their potential. But who is Paul Stamets and what is a stack? How is it done? Read on to find out!

Who is Paul Stamets?

Revered and esteemed mycologist Paul Stamets is an entrepreneur in the use of activated mushrooms. In 1980, Stamets founded Fungi Perfecti to build the bridge between people and fungi. The organization engages in cutting-edge mycological research and innovative mycological solutions. Paul Stamets has written six books on activated mushrooms, and the research team at Fungi Perfecti conducts numerous studies on the effects of activated mushrooms. 

In an interview with Joe Rogan, Stamets described the basis for his mycology work. He states that 650 million years ago, humans separated from Fungi. He continues, explaining that primates share more common ancestry with fungi than any other kingdom. Like humans, fungi take in oxygen and produce carbon dioxide. Our best anti-biotics, like Penicillin, come from fungi because humans and fungi are susceptible to the same bacteria. Stamets hopes to find a way to interface with mushrooms in order to develop rapid responses to catastrophe, just as fungi have done for over a billion years. “We need to engage our fungal allies,” says Stamets. 

Stamets believes humanity is engaged in the sixth Major Extinction on Earth and that microdosing can help humanity make its next quantum leap in consciousness. He calls the process of brain evolution through activated mushroom use epigenetic neurogenesis. 

What is the Paul Stamets Stack?

Stamets proposes a stack method for microdosing activated mushrooms. The “Stamets Stack Formula” consists of .5-1 gram of activated mushrooms, 5-20 grams of Lion’s Mane mushroom, and 100-200 milligrams of Niacin (vitamin B3). Traditionally, activated mushrooms are dosed every 3 to 4 days, but Stamets suggests each person is different and may find different dose schedules and amounts work better for them. 

The activated mushroom strain designated in Stamets’ Stack Formula contains the same amount of active ingredients that were present in the activated mushrooms used in the 1960s to treat people for conditions like anxiety and post-traumatic stress disorders (PTSD). Each capsule of Lion’s Mane contains a half gram of dried fruiting bodies and mycelium, which gets converted to active ingredients upon consumption. Combined with the Niacin, Stamets purports the three elements create a catalytic and synergistic effect, helping the brain renew and expand. 

Stacking Synergy – How the Components Work Together

The Stamets Stack in a nootropic PSI-Vitamin Complex designed for epigenetic neurogenesis; increased creativity, cognition, and wellbeing. Lion’s Mane and activated mushrooms have a complementary relationship to one another, creating what Stamets refers to as the ultimate elixir. Combining the two, according to Stamets, creates a dual capacity for the production of new neurons and neural pathways, as well as repairing present neurological damage. 


Niacin promotes the deliverability of the microdose. Because Niacin works as a flushing agent and acts as a neurotransmitter, it helps distribute the activated mushroom molecules across the blood-brain barrier. Stamets proposes the combination of compounds can be incorporated into other therapies providing unique solutions for medically significant advancements in health, cognition, agility, and the ecology of consciousness. 

Stamets Stack – Final Thoughts

Stamets and Fungi Perfecti continue to collaborate, learn, and conduct microdosing research alongside the global community. It is Stamets’ mission to use policies, technologies, and holistic solutions for the sake of our life support systems. He believes that mushrooms offer powerful, practical solutions that can be put into practice immediately. Stamets believes in both the individual and collective power of activated mushroom therapy.